Anca Zgură, Laurenţia Galeş, Prof.
- Cancer tipuri
- Cancerul colorectal în sarcină
- Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers.
- Dan G. Duda - DF/HCC
- Aceste exemple pot conține termeni colocviali.
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Breast, ovarian, and cervical cancer are the most common cancers diagnosed during pregnancy. The manifestations encountered in colorectal cancer, such as abdominal pain, constipation, vomiting, nausea, rectal bleeding and altered bowel movements, are also found in normal pregnancy.
In rectal cancer mets paper, we present a case of colorectal cancer with hepatic metastasis diagnosed in a year-old preganant woman IIG, 1Pat 32 weeks of pregnancy.
Dan G. Duda
Keywords pregnancy, colorectal cancer, metastasis, teratogencity, chemotherapy Rezumat Incidenţa cancerului colorectal în timpul sarcinii este mică, de un caz la 1. Cancerul mamar, ovarian şi cel cervical sunt cele mai frecvente tipuri de cancer diagnosticate în timpul sarcinii.
Manifestările întâlnite în cancerul colorectal, precum dureri abdominale, constipaţie, vărsături, greaţă, sângerări rectale şi tulburări rectal cancer mets, se întâlnesc şi în timpul sarcinii normale, făcând dificilă diagnosticarea pe parcursul sarcinii.
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În această lucrare vă prezentăm cazul rectal cancer mets paciente de 36 de ani IIG, 1Pîn săptămâna a a de sarcină, diagnosticată cu cancer colorectal, prezentând şi metastaze hepatice. Cuvinte cheie rectal cancer mets colorectal metastaze teratogenitate chimioterapie Introduction The incidence of colorectal cancer during pregnancy is reduced, being estimated at approximately one in every preganancies Breast, ovarian and cervical cancer are the most rectal cancer mets cancers diagnosed during pregnancy 2.
The manifestations encountered in colorectal cancer, such as abdominal pain, constipation, vomiting, nausea, rectal bleeding and altered bowel movements, are also found in normal pregnancy 5.
Most of the colorectal cancers are missed and are diagnosed in advanced stages. Using the antineoplastic agents in a pregnant patient is a difficult decision, with many of safety and efficacy implications 6.
The treatment plan depends on the desire of the pregnant woman, the stage of the disease, the possible teratogenic effects rectal cancer mets the antineoplastic agents and abortion We present in this rectal cancer mets a case of colorectal cancer with hepatic metastasis diagnosed in a patient at 32 weeks of pregnancy.
She also had constipation and anemia. She was initially evaluated by her gynecologist, who suggested a second opinion from a gastroenterologist, who performed an abdominal and pelvic IRM. The rectal cancer mets and pelvic IRM evaluation revealed global hepatomegaly mm cranio caudal right lobe, 97 mm antero-posterior left lobeand more lobular contour space replacement formation.
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The CT scan of the thorax was without secondary pulmonary determinations. There was no family history of cancer. The physical examination at the time was unremarkable, except for normal signs of pregnancy.
The patient was anemic at the time of presentation, the hemoglobin level was 9. After the imagistic and biological evaluation, she was refered to a surgeon, who thought that her pregnancy would make difficult to receive prompt adjuvant therapy. The patient was only week pregnant at the time of diagnosis.
A caesarean section was performed, resulting in the birth of diarree zwanger 7 weken premature baby, weighing g, who received an Apgar score of 9.
During the same operation, a left hemicolectomy and right oophorectomy were also performed.
The histopatological raport revealed a moderate adenocarcinoma G2six nodes were examinated, but only two were positive. The histopatological examination of the ovary showed metastasis of moderate adenocarcinoma Krukenberg ovary.
Before deciding on the initiation of chemotherapy, the patient experienced altered generalized status, medium ascites, pleurisy and gambling edema.
She received a cycle of adjuvant chemotherapy consisting of cetuximab mg.
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The patient tolerated the therapy with supportive treatment and minimal hematologic and non-hematologic toxicities. After one month, we changed the chemotheray cycle with cetuximab, oxaliplatin and rectal cancer mets, due to the improvement of the general state. A follow-up CT scan after three months showed evolution in mild numerical regression of liver lesions.
The hepatomegaly was maintained.