Peritoneal cancer awareness month
Articles of Volume : 54 Issue : 1, March, Statins and heart failure Abstract Full Text Abstract : Chronic heart failure is a syndrome that appears in the evolution of a large majority of cardiovascular diseases.
The main risk factors for chronic heart failure are arterial hypertension, coronary heart disease, diabetes mellitus, obesity, dyslipidemia etc. Over the years, researchers have been intensively studied new approaches and treatments to prevent the development of heart failure, to slow the evolution or to increase survival in patients with this syndrome.
Dyslipidemia is a risk factor for chronic cardiovascular diseases, especially coronary heart disease. HMG-CoA reductase inhibitors statins are largely used for the treatment of hypercholesterolemia and coronary heart disease.
Considering the beneficial effects of statins for the prevention and treatment of cardiovascular diseases, some studies suggested that these drugs can be beneficial in the context of chronic heart failure There are multiple possible explanations for this paradox. Cholesterol is a marker of nutritional status in patients with mild to moderate heart failure.
The congestive hepatopathy of patients with peritoneal cancer awareness month heart failure may lead to decreased liver synthesis of cholesterol2. Also, the intestinal congestion in these patients may impair peritoneal cancer awareness month absorption of cholesterol7.
Studies have found that low serum cholesterol is peritoneal cancer awareness month to the severity of the heart failure, as in other chronic diseases. However, it is not yet known if low cholesterol is the cause of a worse prognosis in heart failure or it is only a marker of more severe disease. On one hand, statins have pleiotropic effects that could be beneficial in heart failure, such as stabilization of atheromatous plaques, inhibition ????????
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? hd proinflammatory cytokine activity and even antiarrhythmic effect8.
On the other hand, statins may be harmful in patients with heart failure, raising their susceptibility to infections, because lipoproteins remove bacterial endotoxins from the circulation9. Treatment with statins reduces the level of coenzyme Q10, which plays a role in the mitochondrial respiration and influences the contractile activity of the myocardium The serum level of coenzyme Q10 is inversely correlated to mortality of patients with heart failure A meta-analysis of 15 studies including 45, patients with heart failure, from whom 22, were treated with statins, revealed that patients who received a statin had a lower all-cause mortality rate and rehospitalization for heart failure CORONA trial suggested that rosuvastatin might be beneficial in patients with ischemic heart disease and systolic heart failure, with NT-proBNP value Dynamics of histological changes in traumatized liver tissues peritoneal cancer awareness month the absence of alcohol intoxication Author : Olena P.
Liver injury is an important cause of death in patients with traumatic injuries. The objective of the study. To study the dynamics of changes in histological parameters of injured liver tissues in case of mechanical trauma, depending on the time of damages in the absence of alcohol intoxication.
Materials and methods.
Lung Cancer Awareness Month at AMRI Hospitals
We examined liver tissue of 52 individuals 38 men and 14 women aged years, who died at known and unknown time in the absence of alcohol in the blood in the Peritoneal cancer awareness month region of Ukraine.
The cause of death was a mechanical trauma. The study was conducted by means of histological, histochemical methods, peritoneal cancer awareness month analysis. Regular histological changes were observed in the area of injured liver tissue. These changes directly depend on the time elapsed since the caused damage.
Usage of the histological method was proved to be expedient for determining the time of injury, both in the isolated liver injury and in combined injuries of the abdominal organs. This method allows to increase the peritoneal cancer awareness month of the results papillary thyroid cancer diagnostic the time of injury.
The study determined changes of histological parameters of liver tissue depending on the time of injury, time of death, presence of traumatic illness, which can help in solving the question on the injury duration. The aim of the study. Dynamic analysis of immunobiological and immunophenotypic parameters in the treatment of patients with NHL, and recognition of immunological remissions. Material and methods. The retrospective study group consisted of patients, admitted between and in the Hematology Clinic of the Republic of Moldova Oncology Institute, with a morphologically confirmed diagnosis of NHL.
We assessed the predominant phenotypic line by indirect immunophenotyping and total concentration of immunoglobulin classes A, M, G according to treatment regimens applied to NHL patients. NHL patients with both aggressive and non-aggressive primary variants after 3 cycles and 6 cycles presented a significant decrease in immunoglobulin A, M, and G indices, on average of 7.
The burden of immunodeficiency and infectious diseases is rapidly increasing worldwide. Thus, it becomes necessary to find effective and affordable immunomodulatory drugs that may modify the response of the immune system. To investigate ultramicroscopic changes that occur in parathyroid glands and thymus of male rats after administration of the immunomodulatory agent imunofan. Thirty-six WAG matured male rats were divided randomly into two peritoneal cancer awareness month.
The first group received imunofan in a dosage of 0. Rodents were sacrificed on the 3rd and 30th day after injection and specimens were dissected out and processed for electron microscopy. The second group served as control and was provided 0. The results showed that imunofan exposure caused marked ultramicroscopic changes in parathyroid glands and thymus of rats.
On the 3rd day after injection, the amount of the active chief cells significantly increases. A significantly increased number peritoneal cancer awareness month secretory granules is recognized as the ultrastructural hallmark of chief cells change.
Thymus in this term of imunofan administration showed no significant ultrastructural changes in comparison to control group. On the 30th day after the administration, the examination revealed that all the glands of the experimental rats have big amounts of active peritoneal cancer awareness month with peritoneal cancer awareness month secretory apparatus.
A significant amount of the secretory granules as the material might be excreted by exocytosis into the intercellular spaces. Electron microscopy of thymus revealed that imunofan injection causes changes in organ as a result of the activation of cell-mediated and antibody-mediated immunity on 30th day.
Apparently, it also causes temporary delay of age-related thymic involution. HOLIAR Abstract Full Text Abstract : The objective of the peritoneal cancer awareness month was to research the dynamics of changes in oxidative and reducing systems in the blood and tissues of the pancreas, lungs and liver during the development of acute necrotizing pancreatitis.
The degree of oxidative modification of peritoneal cancer awareness month proteins was assessed by the method of I. The content of malonic aldehyde in the erythrocytes was determined by the method of I. Stalna and T. The content of ceruloplasmin in the serum was studied by M. Revina method. The level of medium mass molecules was determined by the method of N. The oxidative modification of proteins in the tissues of the pancreas, liver and lungs was carried out using the histochemical method and original techniques.
The development of acute necrotic pancreatitis in the experiment was characterized by an increase in the activity of lipids and proteins in the blood and the oxidative modification of proteins in pancreatocytes, hepatocytes and alveocytes, which is one of the leading mechanisms for their lesion.
The growth of the oxidative modification of proteins in the endothelial cells of the pancreas, liver and lungs in the development of acute pancreatitis contributes to the occurrence of endothelial dysfunction, which is the leading factor in the secondary lesions of these organs. Considering cancer renal stadiul 2 important role of lipoperoxidation and oxidative modification of proteins in the mechanisms of progression of acute necrotic pancreatitis, it is pathogenically grounded to develop new effective methods of systemic and local antioxidant and anti-proteolytic effects.
The experimental part of the work was performed on 16 white rats of the Wistar population. Internal organs and tissues were subjected to the study of the state of receptor binding parameters of labeled C1, C2 serotonin, a1, a2, ß-adreno, D2-dopamine and glucocorticoid type II receptor agonists and antagonists in various regions of the brain and liver.
The functional activity of the receptors was assessed by affinity and the number of binding sites and ligands. The study of the effect of sodium fluoride on the kinetic characteristics of the adrenoreceptors of the membrane fractions of liver cells and the cerebral cortex showed similar dynamic changes in the parameters of receptor binding of both a1-adreno- and ß1-adrenoreceptors. The effect of sodium fluoride was manifested in a decrease in the affinity of the radioligand for peritoneal cancer awareness month and an increase in the number of binding sites for this type of receptors.
Similar dynamics of the kinetic characteristics of a2-adrenoreceptors was found in the cerebellum. The number of binding sites for ß1-adrenoreceptors increased, while their affinity for ligands decreased. In the brainstem, there was a decrease in the affinity of the D2-receptors for ligands and the number of binding sites.
Under conditions of subtoxic effect of sodium fluoride on white rats, a decrease in the affinity of radioligands for C2-receptors and the number of their binding sites in the cerebral cortex was observed. The results of the study show that under the conditions of the formation of fluoride intoxication, structural and functional peritoneal cancer awareness month of the receptor apparatus occur, which confirms the leading role in the development of this pathology of the state of biological membranes.
Changes in the kinetic characteristics of adrenaline a1, a2, ß1serotonin C1, C2dopamine D2 and glucocorticoid receptors confirm the polytropic nature of the action of sodium fluoride on organs, systems and functions of the body. Influence of melatonin on the activity of main enzymes of cori cycle in peritoneal cancer awareness month muscles, heart, liver and kidneys of alloxan-induced diabetic rats Author : Oleksandra Yu. Melatonin, a potent antioxidant agent, is essential for glucose homeostasis.
The objective of the study was to determine the influence of melatonin on basal levels of glucose in blood, activities of glucosephosphatase in kidney and liver, pyruvate kinase in muscles and heart, content of glycogen in muscles and heart of rats with alloxan-induced diabetes. Melatonin injections caused normalization of the elevated serum glucose level in peritoneal cancer awareness month group of rats compared with basal glucose level before treatment.
Melatonin restored all these indexes back to normal level. These findings suggested that melatonin restored the events in Cori cycle by possible activation of glycolysis in skeletal and heart muscles and normalization of gluconeogenesis in liver and kidneys. Dynamics of aldosterone, connective cancer orofaringe tratamento reorganization and glucose level as markers for tuberculosis treatment effectiveness Author : Olga S.
The study was performed on 84 patients with firstly diagnosed multidrug-resistant pulmonary tuberculosis. Aldosterone, free and protein-bound hydroxyproline and glucose levels were measured in all patients.
There was an increase in this index during the first 2 months of treatment in both groups. Protein-bound hydroxyproline level was higher peritoneal cancer awareness month group I by The level of aldosterone at the treatment onset was almost identical in both groups.
After 2 months of treatment, its level decreased in both groups. However, after 2 months of treatment in group I, its index was lower than in group II by Our results suggest that patients with a favorable course of multidrug-resistant tuberculosis have more pronounced decrease in aldosterone level, which may act as a pro-inflammatory agent and free hydroxyproline, which is a marker for the destruction of peritoneal cancer awareness month tissue.
Inverse correlation between protein-bound hydroxyproline and glucose levels confirm the importance of normal glucose concentration for repair process. Optical coherence tomography assessment of structural changes in the optic nerve head and peripapillary retina in idiopathic intracranial hypertension Author : Corina I. Reliable detection of papilledema is essential for establishing the diagnosis of idiopathic intracranial hypertension IIH.
Number 2, 2019
The objective of the study was to assess the role of optical coherence tomography OCT in diagnosing and monitoring papilledema in IIH. Obregia Psychiatry Hospital, Bucharest, Romania. The measurements were compared to a group of 13 subjects with demographic characteristics similar to the study lot, without IIH 7 adults and 6 adolescents over 15 years. The average retinal nerve fiber layer RNFL thickness in the study lot was Fundal photographs and optical coherence tomography can be used with clinical assessment and other visual tests for the diagnosis of papilledema.
Frisén grade determined by direct fundus examination was significantly correlated with OCT parameters reflecting optic nerve head edema. Following the peripapillary RNFL thickness over different check-ups provides a quantitative and sensitive measurement of changes in the papilledema.
The lung cancer has an increased incidence and is associated with the highest death by cancer worldwide.
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It represents peritoneal cancer awareness month heterogenous disease with variability in trends and has a severe socio-economical impact.
That is why it should be continuously monitored, especially in countries without national registries or screening programs. The objective of the study was to identify the epidemiological trend in patients with lung cancer addressed to a Romanian tertiary pneumology service.
We performed a retrospective study on patients diagnosed with lung cancer: the first group of patients diagnosed betweenand the second group of patients diagnosed between Patients peritoneal cancer awareness month the first group had a mean age of The main symptoms were cough The most frequent histological subtype was squamous cell carcinoma peritoneal cancer awareness month Only 35 patients from the first group underwent surgery.
Infrom patients enrolled, 20 were still alive. In the second group the mean age was The most frequent histological subtype was the squamous cell carcinoma Surgery was performed in 65 patients The incidence of lung cancer is increasing, especially in centers without screening programs. There is no change in male prevalence over the years. Despite the fact that, worldwide, adenocarcinoma has increased incidence, in our study squamous cell carcinoma was the main histological subtype.
The delays in diagnosis remain similar. The majority of patients are still diagnosed in advanced stages, when curative treatment cannot peritoneal cancer awareness month applied. Material and method. The study has been conducted for over a year 1. From the total number of patients, we selected and studied those who had in the oral cavity both their temporary teeth and their successor teeth.
In addition to their recording in the oral cavity, where appropriate, the temporary teeth extraction was used to place the definitive ones so that the functions of the dental-maxillary apparatus would not be altered. There were no significant differences between the two sexes.
In the majority of cases, the temporary teeth and the definitive teeth were not in the same plane so that, on the arches line, the temporary ones and the permanent ones had an ectopic position; the temporary teeth had unreabsorbed roots and the final teeth had a defective position. Presence on the arches of both the definitive teeth and the temporal teeth leads to malocclusions that, if not corrected, the entire oral cavity will be damaged.
If teeth with malposition peritoneal cancer awareness month not return to their normal place on the arch, the patient will be directed to the orthodontic specialist. In the past years, the role of social workers in the oncological disease treatment processes has significantly increased.
The objective of the study was to study the psycho-social challenges of oncological children and their families and to define a role of social work in this area. As part of a qualitative study, five interviews were conducted with pediatric oncologists, also 15 in-depth interviews with family members of oncological patients and a focus group with 8 members.
For the quantitative study, 62 beneficiaries and 12 medical specialists were interviewed. The study demonstrated a low level of public awareness. There is a lack of information among both doctors and beneficiaries. However, there are only a few of such organizations. Therefore, many people who need their support have no chance to take such services. Implementing the social work in the pediatric oncology will be a major step toward the medical quality standards.
Surgical treatment of mild to moderate hallux valgus Author : Dmytro V.
