Rotar, Florin V.
Vaccinul anti-HPV – si baietii mor, nu-i asa?
Interleukin 1β is a proinflammatory cytokine that plays a critical role in chronic inflammation and carcinogenesis. Material and method.
A case-control study was realized. The cases were represented by patients diagnosed with cervical intraepithelial neoplasia, positive at HPV HR testing, while controls, negative for intraepithelial neoplasia and negative at HPV HR testing, were included in the control group.
Chi-square statistics had a value of 0.
Odds ration had values of 1. Designul studiului a fost de tip caz-control.
Traducerea «HPV» în 25 de limbi
Lotul de studiu a fost reprezentat de de paciente diagnosticate cu neoplazie cervicală intraepitelială şi pozitive la testarea HPV, iar lotul de control a fost reprezentat de paciente fără leziuni cervicale şi negative la testarea HPV. The mechanisms involved in this transition are extremely complex and only partially understood, immune signal molecules, chemokines, interleukins and the molecules involved in the control of the cellular cycle being involved 1.
Genetic particularities of these molecules could explain why fortunately only a small number of HPV Human Papilloma Virus infected women will develop cervical cancer.
- Copiii, atât fetele cât şi băieţii, ar trebui vaccinaţi începând cu vârsta de 11 ani.
- Benign cancer risks
Interleukin 1b together with interleukin-1a and the antagonist of interleukin 1 belong to the interleukin 1 cytokine hpv virus and seizures, located on a kb segment on chromosome hpv virus and seizures. Interleukin 1b is synthesized mainly by macrophages, but also by other cells of the immune system, with important roles in both acute hpv virus and seizures chronic inflammatory response 2.
vaccin hpv | Nostrabrucanus
The hpv virus and seizures that chronic HPV infection is a mandatory step in cervical carcinogenesis is well known 3. Previously published researches confirmed the contribution of interleukin 1b in the neoplastic process by influencing tumor growth and angiogenesis 4respectively in the induction of chemo resistance 5.
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While performing a search throughout MEDLINE databases we have encountered articles regarding the association between this hpv virus and seizures and human pathologies 8. The presence of this polymorphism was found to be significantly associated with gastroduodenal ulcer 9neoplasia 10pulmonary 11 and pancreatic cancer This particular genetic polymorphism was proved to be related to gynecological and obstetrical conditions: high risk of preterm labor 16spontaneous recurrent abortions 17,18bacterial vaginosis 19polycystic ovary syndrome 20 and uterine leiomyoma The relationship between this genetic polymorphism and cervical cancer was previously analyzed in two small studies in hpv virus and seizures Indian and respectively Korean population but not in Caucasians 22, One hundred and eleven patients with negatives results for intraepithelial lesion with negative HPV HR tests were included in the control group.
The patients were recruited from the corpus of patients hospitalized or only hpv virus and seizures on an ambulatory base during this period at the First Clinic of Obstetrics and Gynecology, Emergency County Hospital Cluj-Napoca, Romania, willing to participate at this study.
The study was approved by the ethical committees and the written consent was obtained for each patient Biological probes collection A gynecological examination was performed for each patient. A cervical cytology was obtained.
Înțelesul "HPV" în dicționarul Engleză
Cervical cytology results were formulated according to Bethesda nomenclature Colposcopic examination was performed for each patient. After the gynecological examination a blood sample was obtained using a 2 ml blood collection tube.
"Sex, Seizures and HPV"
The blood samples were immediately stored at °C. Hpv virus and seizures analysis of cervical samples The cervical cytology was examined by a cytologist after a preliminary Papanicolau staining in the laboratory of the above mentioned hospital.
HPV HR testing was performed using an immunohistochemistry-based kit. DNA extraction. Genetic analysis The genomic DNA was extracted from peripheral leukocytes contained in µl of whole blood using a commercial kit Wizzard Genomic DNA Purification Kit, Promega® according to the producer instructions. The extracted DNA was stored in a freezer at °C.
Genetic variants of Interleukin 1-Beta-511 C>T and cervical intraepithelial neoplasia
Briefly, the PCR reaction was done in 25 µl, total volume containing: Free nuclease water was added in order to reach the total volume. The PCR protocol is shown in Table 2. Table 1.