Due to its high likelihood of progression to carcinoma, endometrial intraepithelial neoplasia EIN demands prompt and specialized intervention. Materials and methods: This month September — November retrospective analysis involved cases of female patients with atypical and non-atypical endometrial hyperplasia investigated and treated at the University Emergency Hospital in Bucharest, Romania. Our purpose was to evaluate the histopathological, immunohistochemical and therapeutical aspects of premalignant endometrial lesions as well as their concurrence with endometrial carcinoma.
Surprisingly, we identified two cases of atypical hyperplasia with focal p53 expression.
Mutation of p53 is a late genetic event seen in endometrial carcinoma which does not usually occur in EIN. Interestingly, these cases did not present endometrial carcinoma on the hysterectomy specimen.
Conclusions: All female patients diagnosed with EIN have an increased risk of endometrial cancer histopathology endometrial carcinoma, as endometrial cancer histopathology are no histologic subdivisions or grades of atypical hyperplasia to further stratify risk for malignancy.
Therefore, we emphasize the importance of accurate detection of premalignant endometrial lesions and exclusion of a coexisting endometrial carcinoma as mandatory prerequisites for proper medical management.
Keywords: non-atypical endometrial hyperplasia, atypical endometrial hyperplasia, EIN, endometrial carcinoma.